Collagen, type IV, alpha 2

Collagen alpha-2(IV) chain is a protein that in humans is encoded by the COL4A2 gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesCOL4A2, ICH, POREN2, collagen type IV alpha 2, collagen type IV alpha 2 chain, BSVD2

External IDsOMIM: 120090; MGI: 88455; HomoloGene: 1390; GeneCards: COL4A2; OMA:COL4A2 - orthologs

Chr.Chromosome 13 (human)^[1]

Quick facts COL4A2, Available structures ...

COL4A2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1LI1
Identifiers
Aliases	COL4A2, ICH, POREN2, collagen type IV alpha 2, collagen type IV alpha 2 chain, BSVD2
External IDs	OMIM: 120090; MGI: 88455; HomoloGene: 1390; GeneCards: COL4A2; OMA:COL4A2 - orthologs
Gene location (Human) Chr. Chromosome 13 (human)[1] Band 13q34 Start 110,305,812 bp[1] End 110,513,209 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8 A1.1|8 5.62 cM Start 11,362,805 bp[2] End 11,499,287 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein decidua pericardium visceral pleura stromal cell of endometrium urethra right coronary artery ascending aorta left coronary artery Descending thoracic aorta Top expressed in epithelium of lens left lung lobe external carotid artery internal carotid artery lactiferous gland stroma of bone marrow ascending aorta umbilical cord decidua aortic valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function extracellular matrix structural constituent protein binding extracellular matrix structural constituent conferring tensile strength Cellular component extracellular matrix extracellular region basement membrane collagen collagen type IV trimer endoplasmic reticulum lumen extracellular exosome extracellular space collagen-containing extracellular matrix Biological process collagen catabolic process negative regulation of angiogenesis cellular response to transforming growth factor beta stimulus extracellular matrix organization endodermal cell differentiation angiogenesis transcription, DNA-templated collagen-activated tyrosine kinase receptor signaling pathway ageing response to activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1284 12827 Ensembl ENSG00000134871 ENSMUSG00000031503 UniProt P08572 P08122 RefSeq (mRNA) NM_001846 NM_009932 RefSeq (protein) NP_001837 NP_034062 Location (UCSC) Chr 13: 110.31 – 110.51 Mb Chr 8: 11.36 – 11.5 Mb PubMed search [3] [4]
Wikidata
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This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.^[7]