Carboxypeptidase A1

Carboxypeptidase A1 is an enzyme that in humans is encoded by the CPA1 gene.^[5]

PDBOrtholog search: PDBe RCSB

AliasesCPA1, CPA, carboxypeptidase A1

External IDsOMIM: 114850; MGI: 88478; HomoloGene: 55609; GeneCards: CPA1; OMA:CPA1 - orthologs

Chr.Chromosome 7 (human)^[1]

Quick facts CPA1, Available structures ...

CPA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2V77, 3FJU, 4UEZ, 4UF4, 4UEE, 4UEF
Identifiers
Aliases	CPA1, CPA, carboxypeptidase A1
External IDs	OMIM: 114850; MGI: 88478; HomoloGene: 55609; GeneCards: CPA1; OMA:CPA1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q32.2 Start 130,380,339 bp[1] End 130,388,114 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 A3.3|6 12.52 cM Start 30,639,217 bp[2] End 30,645,362 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas islet of Langerhans beta cell testicle ectocervix right coronary artery right lobe of liver left uterine tube canal of the cervix right uterine tube Top expressed in pyloric antrum islet of Langerhans secondary oocyte primary oocyte zygote migratory enteric neural crest cell duodenum embryo sexually immature organism Gonadal ridge More reference expression data BioGPS More reference expression data
Gene ontology Molecular function carboxypeptidase activity zinc ion binding peptidase activity exopeptidase activity hydrolase activity metallopeptidase activity metal ion binding metallocarboxypeptidase activity protein binding Cellular component extracellular region extracellular space Biological process proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1357 109697 Ensembl ENSG00000091704 ENSMUSG00000054446 UniProt P15085 Q7TPZ8 RefSeq (mRNA) NM_001868 NM_025350 RefSeq (protein) NP_001859 NP_079626 Location (UCSC) Chr 7: 130.38 – 130.39 Mb Chr 6: 30.64 – 30.65 Mb PubMed search [3] [4]
Wikidata
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Three different forms of human pancreatic procarboxypeptidase A have been isolated. The A1 and A2 forms are monomeric proteins with different biochemical properties. Carboxypeptidase A1 is a monomeric pancreatic exopeptidase. It is involved in zymogen inhibition.^[5]