Y-box-binding protein 3

Y-box-binding protein 3 is a protein that in humans is encoded by the gene YBX3 (previously CSDA).^[5][6][7] The protein YBX3 is involved in the regulation of GM-CSF through binding to DNA at its promotor.^[6] In particular, it is believed to repress expression.^[6]

AliasesYBX3, CSDA, CSDA1, DBPA, ZONAB, Y-box binding protein 3

External IDsOMIM: 603437; MGI: 2137670; GeneCards: YBX3

Chr.Chromosome 12 (human)^[1]

End10,723,323 bp^[1]

Quick facts YBX3, Identifiers ...

YBX3
Identifiers
Aliases	YBX3, CSDA, CSDA1, DBPA, ZONAB, Y-box binding protein 3
External IDs	OMIM: 603437; MGI: 2137670; GeneCards: YBX3
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12p13.2 Start 10,699,089 bp[1] End 10,723,323 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 F3 Start 131,341,818 bp[2] End 131,365,439 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle Skeletal muscle tissue of rectus abdominis muscle of thigh body of tongue Skeletal muscle tissue of biceps brachii vastus lateralis muscle tibialis anterior muscle deltoid muscle triceps brachii muscle thoracic diaphragm Top expressed in seminiferous tubule blood medial head of gastrocnemius muscle external carotid artery internal carotid artery muscle of thigh quadriceps femoris muscle intercostal muscle digastric muscle hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription corepressor activity DNA-binding transcription factor activity mRNA 3'-UTR binding single-stranded DNA binding DNA-binding transcription repressor activity, RNA polymerase II-specific nucleic acid binding double-stranded DNA binding RNA binding DNA-binding transcription factor activity, RNA polymerase II-specific protein binding polysome binding Cellular component polysome bicellular tight junction perinuclear region of cytoplasm nucleus cytoplasm cytosol Biological process male gonad development regulation of transcription, DNA-templated negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress negative regulation of necroptotic process positive regulation of cytoplasmic translation cellular response to tumor necrosis factor positive regulation of organ growth negative regulation of apoptotic process in utero embryonic development negative regulation of transcription by RNA polymerase II transcription, DNA-templated cellular hyperosmotic response negative regulation of skeletal muscle tissue development spermatogenesis response to cold fertilization 3'-UTR-mediated mRNA stabilization Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 8531 56449 Ensembl ENSG00000060138 ENSMUSG00000030189 UniProt P16989 Q9JKB3 RefSeq (mRNA) NM_001145426 NM_003651 NM_011733 NM_139117 RefSeq (protein) NP_001138898 NP_003642 NP_035863 NP_620817 Location (UCSC) Chr 12: 10.7 – 10.72 Mb Chr 6: 131.34 – 131.37 Mb PubMed search [3] [4]
Wikidata
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