Camps quinoline synthesis
Organic synthesis reaction
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The Camps quinoline synthesis (also known as the Camps cyclization) is a chemical reaction whereby an o-acylaminoacetophenone is transformed into two different hydroxyquinolines (products A and B) using hydroxide ion.[1][2][3][4]
| Camps quinoline synthesis | |
|---|---|
| Named after | Rudolph Camps |
| Reaction type | Ring forming reaction |
| Identifiers | |
| RSC ontology ID | RXNO:0000524 |
The relative proportions of the hydroxyquinolines (A and B) produced are dependent upon the reaction conditions and structure of the starting material. Although the reaction product is commonly depicted as a quinoline (the enol form), it is believed that the keto form predominates in both the solid state and in solution, making the compound a quinolone.[5]
An example of the Camps reaction is given below:[5]
The amides of 1,3-enaminoketones react to form pyridinones-2 under similar conditions. [6]