Indium (111In) capromab pendetide
Pharmaceutical compound
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Indium (111In) capromab pendetide (trade name Prostascint) is used to image the extent of prostate cancer.[1] Capromab is a mouse monoclonal antibody which recognizes a protein found on both prostate cancer cells and normal prostate tissue. It is linked to pendetide, a derivative of DTPA.[2] Pendetide acts as a chelating agent for the radionuclide indium-111. Following an intravenous injection of Prostascint, imaging is performed using single-photon emission computed tomography (SPECT).[1]
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Mouse |
| Target | Glutamate carboxypeptidase II |
| Clinical data | |
| Trade names | Prostascint |
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Early trials with yttrium (90Y) capromab pendetide were also conducted.[3]
