Carbonic anhydrase 6

CA6
Identifiers
Aliases	CA6, CA-VI, GUSTIN, carbonic anhydrase 6
External IDs	OMIM: 114780; MGI: 1333786; GeneCards: CA6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3FE4
Enzyme activity
Gene location (Human)
Chr.	Chromosome 1 (human)
End	8,975,092 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	150,285,789 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; skin of arm; ; skin of thigh; ; skin of hip; ; skin of abdomen; ; gonad; ; vulva; ; tail of epididymis; ; hair follicle; ; tongue;
	Top expressed in
	submandibular gland; ; parotid gland; ; lacrimal gland; ; lip; ; skin of external ear; ; temporal muscle; ; respiratory epithelium; ; olfactory epithelium; ; masseter muscle; ; iris;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	carbonate dehydratase activity; zinc ion binding; metal ion binding; lyase activity; protein binding; carbonic anhydrase;
Cellular component	cytoplasm; extracellular region; cytosol; extracellular exosome; extracellular space;
Biological process	bicarbonate transport; detection of chemical stimulus involved in sensory perception of bitter taste; one-carbon metabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	765
	12353
	ENSG00000131686
	ENSMUSG00000028972
	P23280; Q8N4G4
	P18761
	NM_001215; NM_001270500; NM_001270501; NM_001270502
	NM_009802
	NP_001206; NP_001257429; NP_001257430; NP_001257431
	NP_033932
	Wikidata
View/Edit Human	View/Edit Mouse

Carbonic anhydrase 6, also called gustin, is an enzyme that in humans is encoded by the CA6 gene.^[5]^[6]^[7] Early 1970s studies discovered a protein they called "gustin" because of its presence in saliva, and lower-than-normal levels of salivary zinc in individuals with hypogeusia, and this protein was later identified as CA6 in 1998.^[7]^[8]^[9]