Choline/ethanolamine kinase family
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| Choline_kinase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 crystal structure of choline kinase | |||||||||
| Identifiers | |||||||||
| Symbol | Choline_kinase | ||||||||
| Pfam | PF01633 | ||||||||
| Pfam clan | CL0016 | ||||||||
| InterPro | IPR002573 | ||||||||
| |||||||||
In molecular biology, the choline/ethanolamine kinase family includes choline kinase(EC 2.7.1.32) and ethanolamine kinase (EC 2.7.1.82).
Ethanolamine and choline are major membrane phospholipids, in the form of glycerophosphoethanolamine and glycerophosphocholine. Ethanolamine is also a component of the glycosylphosphatidylinositol (GPI) anchor, which is necessary for cell-surface protein attachment.[1] The de novo synthesis of these phospholipids begins with the creation of phosphoethanolamine and phosphocholine by ethanolamine and choline kinases in the first step of the CDP-ethanolamine pathway.[2][3] There are two putative choline/ethanolamine kinases (C/EKs) in the Trypanosoma brucei genome.
Ethanolamine kinase has no choline kinase activity [1] and its activity is inhibited by ADP.[3] Inositol supplementation represses ethanolamine kinase, decreasing the incorporation of ethanolamine into the CDP-ethanolamine pathway and into phosphatidylethanolamine and phosphatidylcholine.[4]