Glycoprotein hormones, alpha polypeptide

CGA
Identifiers
Aliases	CGA, CG-ALPHA, FSHA, GPHA1, GPHa, HCG, LHA, TSHA, Chorionic gonadotropin alpha, glycoprotein hormones, alpha polypeptide, Alpha subunit of glycoprotein hormones, GPA1
External IDs	OMIM: 118850; MGI: 88390; GeneCards: CGA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DZ7, 1E9J, 1FL7, 1HCN, 1HD4, 1HRP, 1QFW, 1XWD, 4AY9, 4MQW
Gene location (Human)
Chr.	Chromosome 6 (human)
End	87,095,106 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	34,907,370 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; placenta; ; buccal mucosa cell; ; testicle; ; tail of epididymis; ; gonad; ; amniotic fluid; ; decidua; ; islet of Langerhans; ; hair follicle;
	Top expressed in
	pituitary gland; ; median eminence; ; anterior pituitary; ; pars tuberalis; ; arcuate nucleus; ; pars distalis of adenohypophysis; ; morula; ; embryo; ; outer nuclear layer; ; blastocyst;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; hormone activity; follicle-stimulating hormone activity;
Cellular component	Golgi lumen; extracellular region; extracellular space; follicle-stimulating hormone complex;
Biological process	cell-cell signaling; peptide hormone processing; positive regulation of cell population proliferation; positive regulation of transcription by RNA polymerase II; signal transduction; positive regulation of cell migration; regulation of transcription by RNA polymerase II; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; positive regulation of steroid biosynthetic process; thyroid hormone generation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	1081
	12640
	ENSG00000135346
	ENSMUSG00000028298
	P01215
	P01216
	NM_001252383; NM_000735
	NM_009889
	NP_000726; NP_001239312
	NP_034019
	Wikidata
View/Edit Human	View/Edit Mouse

Glycoprotein hormones, alpha polypeptide is a protein that in humans is encoded by the CGA gene.^[5]

AliasesCGA, CG-ALPHA, FSHA, GPHA1, GPHa, HCG, LHA, TSHA, Chorionic gonadotropin alpha, glycoprotein hormones, alpha polypeptide, Alpha subunit of glycoprotein hormones, GPA1

External IDsOMIM: 118850; MGI: 88390; GeneCards: CGA

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 6 (human)^[1]

Quick facts CGA, Identifiers ...

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Thyroid-stimulating hormone (TSH) and the gonadotropin hormones human chorionic gonadotropin (hCG), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) are heterodimers consisting of alpha and beta subunits (also called chains) that are associated non-covalently. The alpha subunits of these four human glycoprotein hormones are identical; however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family.^[6] CGA levels are regulated by ELAVL1/HuR, and the small molecule Eltrombopag, which targets HuR/RNA interactions, has been shown to reduce CGA levels in human cultured cells.^[7]

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Glycoprotein hormones, alpha polypeptide

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