Trans-cinnamate 4-monooxygenase
Class of enzymes
From Wikipedia, the free encyclopedia
Trans-cinnamate 4-monooxygenase (EC 1.14.14.91) is an enzyme that catalyzes the chemical reaction
| Trans-cinnamate 4-monooxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.14.14.91 | ||||||||
| CAS no. | 9077-75-2 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The four substrates of this enzyme are cinnamic acid, reduced nicotinamide adenine dinucleotide phosphate (NADPH), oxygen, and a proton. Its products are p-coumaric acid, oxidised NADP+, and water. It participates in phenylalanine metabolism and phenylpropanoid biosynthesis, especially of flavonoids in plants.[1][2][3]
The enzyme is a cytochrome P450 protein containing heme. It requires a partner cytochrome P450 reductase for functional expression. This uses nicotinamide adenine dinucleotide phosphate (NADPH).[4]
Nomenclature
The systematic name of this enzyme class is trans-cinnamate,NADPH:oxygen oxidoreductase (4-hydroxylating). Other names in common use include:[4]
- cinnamic acid 4-hydroxylase,
- oxygenase, cinnamate 4-mono-,
- CA4H (gene name),
- CYP73A1 (gene name),
- cytochrome P450 cinnamate 4-hydroxylase,
- cinnamate 4-hydroxylase,
- cinnamate 4-monooxygenase,
- cinnamate hydroxylase,
- cinnamic 4-hydroxylase,
- cinnamic acid 4-monooxygenase,
- cinnamic acid p-hydroxylase,
- hydroxylase, cinnamate 4-,
- t-cinnamic acid hydroxylase,
- trans-cinnamate 4-hydroxylase, and
- trans-cinnamic acid 4-hydroxylase.
