Comorbidity–polypharmacy score
Measure of severity of comorbidities
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In medicine, the Comorbidity–polypharmacy score (CPS) is a measure of overall severity of comorbidities.[1] It is defined as the simple sum of the number of known comorbidities (concurrent conditions) and pre-admission medications taken by the patient (polypharmacy), as a surrogate for the “intensity” of the comorbidities.[2]
This score has been tested and validated extensively in the trauma population, demonstrating good correlation with mortality, morbidity, triage, and hospital readmissions.[3][4][5] Increasing levels of CPS were associated with significantly lower 90-day survival in the original study of the score in trauma population.[3]
Comparison with other comorbidity measures
The test is similar to the Charlson Comorbidity Index (CCI), but CPS also considers the number of medications taken, which is not a parameter in CCI. Additionally, CPS considers a wider range of comorbidities than CCI, and assigns the same weight to each.[2] A study comparing the two metrics found that CCI was a better predictor of mortality than CPS in older trauma patients.[6]
