Cumberland Presbytery was the heart of the Second Great Awakening. Although ministers in support of the Revival of 1800 generally dominated the presbytery, the anti-revival faction dominated the Kentucky Synod. In 1806, differences between the presbytery and the synod over the revival, ordination standards for ministers, and the literal interpretation of the Westminster Confession of Faith resulted in Cumberland Presbytery being dissolved back into Transylvania Presbytery.
The former members of Cumberland Presbytery fought for their position for a number of years in the hope that the Kentucky Synod would reconsider. The General Assembly of the Presbyterian Church agreed that the synod had made an error of judgement, but it took no action to reinstate Cumberland Presbytery. In 1810, the former members of Cumberland Presbytery reformed the presbytery as the Cumberland Presbyterian Church.