Cys/Met metabolism PLP-dependent enzyme family
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| Cys_Met_Meta_PP | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 cystathionine beta-lyase (cbl) from escherichia coli in complex with n-hydrazinocarbonylmethyl-2-trifluoromethyl-benzamide | |||||||||
| Identifiers | |||||||||
| Symbol | Cys_Met_Meta_PP | ||||||||
| Pfam | PF01053 | ||||||||
| Pfam clan | CL0061 | ||||||||
| InterPro | IPR000277 | ||||||||
| PROSITE | PDOC00677 | ||||||||
| SCOP2 | 1cs1 / SCOPe / SUPFAM | ||||||||
| CDD | cd00614 | ||||||||
| |||||||||
In molecular biology, the Cys/Met metabolism PLP-dependent enzyme family is a family of proteins including enzymes involved in cysteine and methionine metabolism which use PLP (pyridoxal-5'-phosphate) as a cofactor.[1]
PLP is employed as it binds to amino groups and stabilises carbanion intermediates. PLP enzymes exist in their resting state as a Schiff base, the aldehyde group of PLP forming a linkage with the epsilon-amino group of an active site lysine residue on the enzyme. The alpha-amino group of the substrate displaces the lysine epsilon-amino group, in the process forming a new aldimine with the substrate. This aldimine is the common central intermediate for all PLP-catalysed reactions, enzymatic and non-enzymatic.[2]