Dihydropyrimidine dehydrogenase (NADP+)
Class of enzymes
From Wikipedia, the free encyclopedia
In enzymology, dihydropyrimidine dehydrogenase (NADP+) (EC 1.3.1.2) is an enzyme that catalyzes the chemical reaction
| dihydropyrimidine dehydrogenase (NADP+) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 Dihydroprymidine dehydrogenase dimer, Sus scrofa | |||||||||
| Identifiers | |||||||||
| EC no. | 1.3.1.2 | ||||||||
| CAS no. | 9029-01-0 | ||||||||
| Alt. names | Dihydrothymine dehydrogenase | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In the catabolism of uracil, the enzyme converts uracil to dihydrouracil using nicotinamide adenine dinucleotide phosphate (NADPH) as its cofactor. It can also act on thymine to give dihydrothymine.[1][2]
In humans the enzyme is encoded by the DPYD gene.[3][4] It is the initial and rate-limiting step in pyrimidine catabolism.[citation needed] It is also involved in the degradation of the chemotherapeutic drugs 5-fluorouracil and tegafur.[5] It participates in beta-alanine metabolism and pantothenate and coa biosynthesis.
Terminology
The systematic name of this enzyme class is 5,6-dihydrouracil:NADP+ 5-oxidoreductase.
Other names in common use include:
- dihydrothymine dehydrogenase
- dihydrouracil dehydrogenase (NADP+)
- 4,5-dihydrothymine: oxidoreductase
- DPD
- DHPDH
- dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide, phosphate)
- DHU dehydrogenase
- hydropyrimidine dehydrogenase
- dihydropyrimidine dehydrogenase (NADP+)
Structural studies
Function
The protein is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Genetic deficiency of this enzyme results in an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy.[4]
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles.[§ 1]
Fluorouracil (5-FU) Activity edit
- The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".
See also
- Dihydropyrimidine dehydrogenase deficiency, a genetic disorder
- Cancer pharmacogenomics
