CCAR2

CCAR2
Identifiers
Aliases	CCAR2, DBC-1, DBC1, KIAA1967, NET35, p30 DBC, p30DBC, cell cycle and apoptosis regulator 2
External IDs	OMIM: 607359; MGI: 2444228; HomoloGene: 10910; GeneCards: CCAR2; OMA:CCAR2 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	22,620,964 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	70,391,260 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; right uterine tube; ; right testis; ; left testis; ; granulocyte; ; skin of leg; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; appendix;
	Top expressed in
	ventricular zone; ; spermatocyte; ; neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; renal corpuscle; ; medullary collecting duct; ; neural tube; ; ganglionic eminence; ; superior frontal gyrus; ; primary visual cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	RNA polymerase II complex binding; enzyme inhibitor activity; protein binding; enzyme binding; RNA binding; nuclear receptor coactivator activity;
Cellular component	cytoplasm; nucleoplasm; DBIRD complex; mitochondrial matrix; spliceosomal complex; nucleus;
Biological process	mitochondrial fragmentation involved in apoptotic process; negative regulation of catalytic activity; regulation of transcription, DNA-templated; regulation of protein stability; positive regulation of DNA damage checkpoint; rhythmic process; positive regulation of canonical Wnt signaling pathway; mRNA processing; regulation of DNA-templated transcription, elongation; regulation of protein deacetylation; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; Wnt signaling pathway; transcription, DNA-templated; cellular response to DNA damage stimulus; regulation of circadian rhythm; negative regulation of cell growth; RNA splicing; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of apoptotic process; regulation of cellular response to heat; cell cycle; negative regulation of transcription, DNA-templated; response to UV; apoptotic process; positive regulation of nucleic acid-templated transcription;
	Sources:Amigo / QuickGO
Orthologs
	57805
	219158
	ENSG00000158941
	ENSMUSG00000033712
	Q8N163
	Q8VDP4
	NM_021174; NM_199205; NM_001363068; NM_001363069; NM_001393997
	NM_146055
	NP_066997; NP_001349997; NP_001349998
	NP_666167
	Wikidata
View/Edit Human	View/Edit Mouse

Cell cycle and apoptosis regulator protein 2, also known as Deleted in breast cancer 1 (DBC-1), and KIAA1967, is a protein which in humans is encoded by the CCAR2 gene.^[5]^[6]^[7]