DLL3
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Delta-like 3 (Drosophila), also known as DLL3, is a protein which in humans is encoded by the DLL3 gene.[5] Two transcript variants encoding distinct isoforms have been identified for this gene.
| DLL3 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | DLL3, SCDO1, pu, pudgy, delta like canonical Notch ligand 3 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 602768; MGI: 1096877; GeneCards: DLL3 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
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Function
This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain.[6] Expression of DLL3 is highest in fetal brain. It plays a key role in somitogenesis within the paraxial mesoderm.[7]
Clinical significance
Mutations in this gene cause the autosomal recessive genetic disorder Jarcho-Levin syndrome.[8]
Experimental drugs targeting DLL3 have also been investigated as possible treatments for certain types of lung and neuroendocrine cancer, Tarlatamab and rovalpituzumab tesirine are two prominent examples.[9][10]
