Dextrin dextranase
Class of enzymes
From Wikipedia, the free encyclopedia
In enzymology, a dextrin dextranase (EC 2.4.1.2) is an enzyme that catalyzes the chemical reaction
- (1,4-alpha-D-glucosyl)n + (1,6-alpha-D-glucosyl)m (1,4-alpha-D-glucosyl)n-1 + (1,6-alpha-D-glucosyl)m+1
| dextrin dextranase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.4.1.2 | ||||||||
| CAS no. | 9032-13-7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
Thus, the two substrates of this enzyme are (1,4-alpha-D-glucosyl)n and (1,6-alpha-D-glucosyl)m, whereas its two products are (1,4-alpha-D-glucosyl)n-1 and (1,6-alpha-D-glucosyl)m+1.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is 1,4-alpha-D-glucan:1,6-alpha-D-glucan 6-alpha-D-glucosyltransferase. Other names in common use include dextrin 6-glucosyltransferase, and dextran dextrinase. If the enzyme predominantly catalyzes the synthesis of dextran from dextrin, the name "dextran dextrinase" is considered more appropriate.
In 2025, the three-dimensional structure of dextran dextrinase from Gluconobacter oxydans was reported. The enzyme shows a strong structural similarity to glucoamylases and glucodextranases, which hydrolyze dextrin and dextran. However, a spatial shift of about 1.5 Å in the catalytic residues enables dextran dextrinase to catalyze transglucosylation reactions.
