Dihydroxy-acid dehydratase
From Wikipedia, the free encyclopedia
The enzyme dihydroxy-acid dehydratase (EC 4.2.1.9) catalyzes the chemical reaction
- 2,3-dihydroxy-3-methylbutanoate 3-methyl-2-oxobutanoate + H2O
This enzyme participates in valine, leucine and isoleucine biosynthesis and pantothenate and coenzyme A (CoA) biosynthesis.
Nomenclature
This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 2,3-dihydroxy-3-methylbutanoate hydro-lyase (3-methyl-2-oxobutanoate-forming). Other names in common use include
- acetohydroxyacid dehydratase,
- α,β-dihydroxyacid dehydratase,
- 2,3-dihydroxyisovalerate dehydratase,
- α,β-dihydroxyisovalerate dehydratase,
- dihydroxy acid dehydrase,
- DHAD,
- and 2,3-dihydroxy-acid hydro-lyase.
References
Further reading
- Kanamori M, Wixom RL (Mar 1963). "Studies in valine biosynthesis. V. Characteristics of the purified dihydroxyacid dehydratase from spinach leaves". The Journal of Biological Chemistry. 238 (3): 998–1005. doi:10.1016/S0021-9258(18)81249-2. PMID 13962154.
- Myers JW (May 1961). "Dihydroxy acid dehydrase: an enzyme involved in the biosynthesis of isoleucine and valine". The Journal of Biological Chemistry. 236 (5): 1414–8. doi:10.1016/S0021-9258(18)64188-2. PMID 13727223.
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