Dolutegravir/lamivudine/tenofovir
Combination drug for HIV
From Wikipedia, the free encyclopedia
Dolutegravir/lamivudine/tenofovir (DTG/3TC/TDF) is a fixed-dose combination antiretroviral medication used to treat HIV/AIDS.[2] It is a combination of dolutegravir, lamivudine, and tenofovir disoproxil.[2] As of 2019[update], it is listed by the World Health Organization (WHO) as the first line treatment for adults, with tenofovir/lamivudine/efavirenz as an alternative.[3] It is taken by mouth.[4]
| Combination of | |
|---|---|
| Dolutegravir | Integrase strand transfer inhibitor |
| Lamivudine | Nucleoside reverse transcriptase inhibitor |
| Tenofovir disoproxil | Nucleoside reverse transcriptase inhibitor |
| Clinical data | |
| Other names | Tenofovir/lamivudine/dolutegravir (TLD) |
| Routes of administration | By mouth |
| ATC code | |
| Legal status | |
| Legal status | |
Side effects may include trouble sleeping, weight gain, and rash.[3][4] While there are concerns that use during pregnancy results in a 0.2% increased risk of neural tube defects in the baby, this does not rule out its use.[3] Use remains recommended after the first trimester.[3] Use is not recommended in those with kidney problems.[4] The combination is a type of antiretroviral therapy.[3]
It is on the World Health Organization's List of Essential Medicines.[5] In some countries it is available as a generic medication.[6] It was approved for medical use in the United States in May 2026.[1]
Medical uses
As of 2019, it is listed by the World Health Organization (WHO) as the first-line treatment for adults with HIV/AIDS, with tenofovir/lamivudine/efavirenz as an alternative.[3] It may be used in people with both HIV and tuberculosis, however if the person is on rifampicin a larger dose of dolutegravir is needed.[3]
Side effects
Side effects may include trouble sleeping and weight gain.[3] While there are concerns that use during pregnancy results in a 0.2% increased risk of neural tube defects in the baby, this does not rule out its use.[3] Use remains recommended after the first trimester.[3] It should not be used with dofetilide.[4]
