Oxazosulfyl

Oxazosulfyl is an insecticide that was developed by Sumitomo and introduced to the market in Japan in 2021 for use against insect pests on rice.^[1] The molecule has two different sulfonyl groups.

Quick facts Names, Identifiers ...

Oxazosulfyl

Names
IUPAC name 2-(3-ethylsulfonyl-2-pyridinyl)-5-(trifluoromethylsulfonyl)-1,3-benzoxazole
Identifiers
CAS Number	1616678-32-0 Y
3D model (JSmol)	Interactive image
ChemSpider	62285804
ECHA InfoCard	100.355.735
EC Number	881-235-3
PubChem CID	90258515
UNII	Q63MCC2PTT Y
CompTox Dashboard (EPA)	DTXSID601337387
InChI InChI=1S/C15H11F3N2O5S2/c1-2-26(21,22)12-4-3-7-19-13(12)14-20-10-8-9(5-6-11(10)25-14)27(23,24)15(16,17)18/h3-8H,2H2,1H3 Key: PTQBEFQWTBZMED-UHFFFAOYSA-N
SMILES CCS(=O)(=O)C1=C(N=CC=C1)C2=NC3=C(O2)C=CC(=C3)S(=O)(=O)C(F)(F)F
Properties
Chemical formula	C₁₅H₁₁F₃N₂O₅S₂
Molar mass	420
Hazards
GHS labelling:
Pictograms
Signal word	Warning
Hazard statements	H410
Precautionary statements	P273, P391, P501
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

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Oxazosulfyl works by inhibiting the vesicular acetylcholine transporter (VAChT) and was allocated to IRAC group 37.^[2] This inhibition results in rapid paralysis of the insect, which onsets a few minutes after application, and lasts for several days.

Oxazosulfyl is the first and until now only insecticide in the IRAC group 37. The class has not been given a name by IRAC, but Sumitomo propose the name "sulfyl" for the class.^[1]

Oxazosulfyl is used mainly in rice seed boxes. It controls a broad spectrum of rice pests in the orders of hemiptera, lepidoptera, and coleoptera. Some of the target insects are the brown planthopper (Nilaparvata lugens), the white-backed planthopper (Sogatella furcifera), the small brown planthopper (Laodelphax striatellus) and the rice leaf beetle (Oulema oryzae).^[3]