SKF-64139

SKF-64139 is a synthetic tetrahydroisoquinoline (THIQ) derivative that functions as a potent and selective inhibitor of phenylethanolamine N-methyltransferase (PNMT), the enzyme that catalyzes the conversion of norepinephrine to epinephrine in both the adrenal medulla and the central nervous system. By lowering epinephrine levels through PNMT inhibition, SKF-64139 has been widely used as a research tool to study the physiological functions of epinephrine, particularly its roles in cardiovascular regulation and metabolic processes.^[1]

Other namesSK&F 64139, DCTQ.

CAS Number

• 61563-24-4

PubChem CID

• 123919

DrugBank

• DB08550

Quick facts Clinical data, Other names ...

SKF-64139

Clinical data
Other names	SK&F 64139, DCTQ.
Identifiers
IUPAC name 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
CAS Number	61563-24-4
PubChem CID	123919
DrugBank	DB08550
ChemSpider	110451
UNII	A0EP5O913J
ChEBI	CHEBI:160129
ChEMBL	ChEMBL287837
Chemical and physical data
Formula	C9H9Cl2N
Molar mass	202.08 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1CNCC2=C1C=CC(=C2Cl)Cl
InChI InChI=1S/C9H9Cl2N/c10-8-2-1-6-3-4-12-5-7(6)9(8)11/h1-2,12H,3-5H2 Key:WFPUBEDBBOGGIQ-UHFFFAOYSA-N

Close

This compound also exhibits additional actions, such as weak monoamine oxidase (MAO) inhibition at higher doses, which may contribute to broader neurochemical and hemodynamic effects.^[2] Additionally, SKF-64139 is an alpha-2 blocker^[3] that lowers the blood pressure in hypertensive rats.^[4]