Manogepix

Manogepix (E1210) is an pyridine-isoxazole-based broad-spectrum antifungal.^[1] Manogepix targets an enzyme involved in the post-translational modification of fungal proteins.

Other namesE1210, APX001A

ATC code

• None

CAS Number

• 936339-60-5

PubChem CID

• 16719049

Quick facts Clinical data, Other names ...

Manogepix

Clinical data
Other names	E1210, APX001A
ATC code	None
Identifiers
IUPAC name 3-(3-(4-((pyridin-2-yloxy)methyl)benzyl)isoxazol-5-yl)pyridin-2-amine
CAS Number	936339-60-5
PubChem CID	16719049
ChemSpider	17623449
UNII	7B1P18ID9L
ChEMBL	ChEMBL4533578
CompTox Dashboard (EPA)	DTXSID601045473
Chemical and physical data
Formula	C12H18N4O2
Molar mass	250.302 g·mol−1
3D model (JSmol)	Interactive image
SMILES c1ccnc(c1)OCc2ccc(cc2)Cc3cc(on3)c4cccnc4N
InChI InChI=1S/C21H18N4O2/c22-21-18(4-3-11-24-21)19-13-17(25-27-19)12-15-6-8-16(9-7-15)14-26-20-5-1-2-10-23-20/h1-11,13H,12,14H2,(H2,22,24) Key:WSEKTEUGRLFBSE-UHFFFAOYSA-N

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Manogepix is the active metabolite of the prodrug fosmanogepix.^[2]