E74 like ETS transcription factor 3

ELF3
Identifiers
Aliases	ELF3, EPR-1, ERT, ESE-1, ESX, E74 like ETS transcription factor 3
External IDs	OMIM: 602191; MGI: 1101781; GeneCards: ELF3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2E8P
Gene location (Human)
Chr.	Chromosome 1 (human)
End	202,017,183 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	135,186,306 bp
RNA expression pattern
	Top expressed in
	olfactory zone of nasal mucosa; ; mucosa of transverse colon; ; rectum; ; pancreatic ductal cell; ; gallbladder; ; body of pancreas; ; minor salivary glands; ; islet of Langerhans; ; right uterine tube; ; palpebral conjunctiva;
	Top expressed in
	corneal stroma; ; pyloric antrum; ; epithelium of stomach; ; mucous cell of stomach; ; blastocyst; ; duodenum; ; colon; ; left colon; ; medulla of thymus; ; crypt of lieberkuhn of small intestine;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity; transcription coactivator activity; DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nucleus; Golgi apparatus; cytosol; nucleoplasm;
Biological process	cell differentiation; regulation of transcription, DNA-templated; epithelial cell differentiation; regulation of transcription by RNA polymerase II; anatomical structure morphogenesis; extracellular matrix organization; transcription by RNA polymerase II; transcription, DNA-templated; multicellular organism development; positive regulation of transcription, DNA-templated; epidermis development; inflammatory response; negative regulation of transcription, DNA-templated; blastocyst development; positive regulation of transcription by RNA polymerase II; mammary gland involution; positive regulation of Notch signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	1999
	13710
	ENSG00000163435
	ENSMUSG00000003051
	P78545
	Q3UPW2
	NM_001114309; NM_004433
	NM_001163131; NM_007921
	NP_001107781; NP_004424
	NP_001156603; NP_031947
	Wikidata
View/Edit Human	View/Edit Mouse

ETS-related transcription factor Elf-3 is a protein that in humans is encoded by the ELF3 gene. It is a member of the ETS transcription factor family^[5] and was named for its homology to E74, a transcription factor from Drosophila melanogaster.^[6]