Epstein–Barr virus nuclear antigen 3

The Epstein–Barr virus nuclear antigen 3 (EBNA-3) is a family of viral proteins associated with the Epstein–Barr virus. A typical EBV genome contains three such proteins:^[1]

• EBNA-3A (P12977, EBNA-3; BLRF3-BERF1)
• EBNA-3B (P03203, EBNA-4; BERF2A-BERF2B)
• EBNA-3C (P03204, EBNA-6, EBNA-4B; BERF3-BERF4)

These genes also bind the host RBP-Jκ protein.^[2]

EBNA-3C can recruit a ubiquitin ligase and has been shown to target cell-cycle regulators such as retinoblastoma protein (pRb).^[3][4]