LGTN

Protein-coding gene in the species Homo sapiens From Wikipedia, the free encyclopedia

Ligatin, otherwise known as eIF2D, is a protein that in humans is encoded by the LGTN gene.[5][6] This protein is not a component of the heterotrimeric eIF2 complex, but instead functions in different pathways of eukaryotic translation.

AliasesEIF2D, HCA56, LGTN, eukaryotic translation initiation factor 2D
End206,612,465 bp[1]
Quick facts EIF2D, Identifiers ...
EIF2D
Identifiers
AliasesEIF2D, HCA56, LGTN, eukaryotic translation initiation factor 2D
External IDsOMIM: 613709; MGI: 109342; HomoloGene: 38244; GeneCards: EIF2D; OMA:EIF2D - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001201478
NM_006893

NM_001136070
NM_010709

RefSeq (protein)

NP_001188407
NP_008824

NP_001129542
NP_034839

Location (UCSC)Chr 1: 206.57 – 206.61 MbChr 1: 131.08 – 131.12 Mb
PubMed search[3][4]
Wikidata
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Function

This gene encodes a protein receptor that localizes phosphoglycoproteins within endosomes and at the cell periphery. This trafficking receptor for phosphoglycoproteins may play a role in neuroplasticity by modulating cell-cell interactions, intracellular adhesion, and protein binding at membrane surfaces. In hippocampal neurons, long-lasting down-regulation of ligation mRNA levels occurs via post-transcriptional RNA processing following glutamate receptor activation. This protein contains single PUA and SUI1 domains and these domains may function in RNA binding and translation initiation, respectively.[6]

See also

References

Further reading

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