EPH receptor B2
Protein-coding gene in the species Homo sapiens
From Wikipedia, the free encyclopedia
Ephrin type-B receptor 2 is a protein that in humans is encoded by the EPHB2 gene.[5]
Function
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.[6]
Animal studies
EphB2 is part of the NMDA signaling pathway and restoring expression rescues cognitive function in an animal model of Alzheimer's disease.[7]
A recessive EphB2 gene is responsible for the crested-feather mutation in pigeons.[8]
