Endothelin converting enzyme 1

ECE1
Identifiers
Aliases	ECE1, ECE, endothelin converting enzyme 1
External IDs	OMIM: 600423; MGI: 1101357; GeneCards: ECE1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3DWB
Enzyme activity
Gene location (Human)
Chr.	Chromosome 1 (human)
End	21,345,572 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	137,692,540 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; left adrenal cortex; ; right adrenal gland; ; popliteal artery; ; tibial arteries; ; right adrenal cortex; ; right lung; ; right coronary artery; ; gastric mucosa; ; canal of the cervix;
	Top expressed in
	aortic valve; ; right lung lobe; ; endothelial cell of lymphatic vessel; ; ascending aorta; ; islet of Langerhans; ; gastrula; ; lip; ; pituitary gland; ; internal carotid artery; ; external carotid artery;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	endopeptidase activity; metal ion binding; peptide hormone binding; peptidase activity; protein binding; hydrolase activity; metallopeptidase activity; protein homodimerization activity; metalloendopeptidase activity; zinc ion binding;
Cellular component	Weibel-Palade body; integral component of membrane; vesicle; endosome; membrane; lysosomal membrane; intrinsic component of endosome membrane; perinuclear region of cytoplasm; extracellular exosome; external side of plasma membrane; early endosome; plasma membrane;
Biological process	endothelin maturation; bradykinin catabolic process; regulation of systemic arterial blood pressure by endothelin; embryonic digit morphogenesis; ear development; hormone catabolic process; proteolysis; development of the heart; calcitonin catabolic process; regulation of vasoconstriction; substance P catabolic process; pharyngeal system development; positive regulation of receptor recycling; protein processing; peptide hormone processing;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	1889
	230857
	ENSG00000117298
	ENSMUSG00000057530
	P42892
	Q4PZA2
	NM_001113347; NM_001113348; NM_001113349; NM_001397
	NM_199307; NM_001369177; NM_001369178; NM_001369179
	NP_001106818; NP_001106819; NP_001106820; NP_001388; NP_001106820.1
	NP_955011; NP_001356106; NP_001356107; NP_001356108
	Wikidata
View/Edit Human	View/Edit Mouse

Endothelin converting enzyme 1, also known as ECE1, is an enzyme which in humans is encoded by the ECE1 gene.^[5]^[6]^[7] It is inhibited by phosphoramidon.^[8] ECE1 also mediates melanin production through breaking down inactive Big-EDN1 to produce an active EDN1 in keratinocytes and endothelial cells. ^[9]