Fatty acid oxidation inhibitors
From Wikipedia, the free encyclopedia
Fatty acid oxidation inhibitors are a new potent class of drugs used in treatment of stable angina pectoris and an addition in treatment of chronic heart failure.
Drugs
- CPT-I inhibitors: etomoxir, oxfenicine, perhexiline
CPT-I (carnitine palmitoyl transferase) converts fatty acyl-CoA to fatty acyl-carnitine. - Carnitine biosynthesis inhibitor: mildronate[1]
- 3-KAT inhibitors: trimetazidine
3-KAT (3-ketoacyl-coenzyme A thiolase) inhibitors directly inhibits fatty acid beta-oxidation. - pFOX directly inhibits fatty acid beta-oxidation.[2]