Fcα/μR

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Structures	Swiss-model
Domains	InterPro

Fc receptor, IgA, IgM, high affinity
Fc receptor, IgA, IgM, high affinity
Identifiers
Symbol	FCAMR, CD351
NCBI gene	83953
HGNC	24692
OMIM	605484
RefSeq	NM_032029
UniProt	Q96SA2
Other data
Locus	Chr. 1 q32.1
Structures
Search for
Structures	Swiss-model
Domains	InterPro

FCAMR
Identifiers
Aliases	FCAMR, CD351, FCA/MR, FKSG87, Fc fragment of IgA and IgM receptor, Fc alpha and mu receptor, Fcalpha/muR
External IDs	OMIM: 605484; MGI: 1927803; GeneCards: FCAMR
Gene location (Human)
Chr.	Chromosome 1 (human)
End	206,970,625 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	130,742,477 bp
RNA expression pattern
	Top expressed in
	human kidney; ; mucosa of ileum; ; lymph node; ; appendix; ; right lobe of liver; ; mucosa of transverse colon; ; tonsil; ; renal cortex; ; rectum; ; duodenum;
	Top expressed in
	right kidney; ; proximal tubule; ; zygote; ; transitional epithelium of urinary bladder; ; olfactory epithelium; ; secondary oocyte; ; human kidney; ; lip; ; esophagus; ; neural layer of retina;
	More reference expression data
	n/a
Orthologs
Databases	NCBI: entry; OMA: entry
	83953
	64435
	ENSG00000162897
	ENSMUSG00000026415
	Q8WWV6
	Q2TB54
	NM_001122979; NM_001122980; NM_001170631; NM_032029
	NM_001170632; NM_144960
	NP_001116451; NP_001164102; NP_114418
	NP_001164103; NP_659209
	Wikidata
View/Edit Human	View/Edit Mouse

Fcα/μR, also known as is CD351 (Cluster of Differentiation 351), is an Fc receptor that binds IgM with high affinity and IgA with a 10-fold lower affinity.^[5] In mice the receptor is expressed on macrophages, follicular dendritic cells, marginal zone B cells, follicular B cells, and kidney tubular epithelial cells. In humans expression has been described on intestinal lamina propria cells, Paneth cells, follicular dendritic cells in tonsils, activated macrophages and some types of pre-germinal centre IgD+/CD38+ B cells.