Fibrinogen gamma chain

FGG
Identifiers
Aliases	FGG, fibrinogen gamma chain
External IDs	OMIM: 134850; MGI: 95526; HomoloGene: 429; GeneCards: FGG; OMA:FGG - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DUG, 1FIB, 1FIC, 1FID, 1FZA, 1FZB, 1FZC, 1FZE, 1FZF, 1FZG, 1LT9, 1LTJ, 1N86, 1N8E, 1RE3, 1RE4, 1RF0, 1RF1, 2A45, 2FFD, 2FIB, 2H43, 2HLO, 2HOD, 2HPC, 2HWL, 2OYH, 2OYI, 2Q9I, 2VDO, 2VDP, 2VDQ, 2VDR, 2VR3, 2XNX, 2XNY, 2Y7L, 2Z4E, 3BVH, 3E1I, 3FIB, 3GHG, 3H32, 3HUS, 4B60
Gene location (Human)
Chr.	Chromosome 4 (human)
End	154,612,967 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	82,922,356 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; beta cell; ; decidua; ; testicle; ; lower lobe of lung; ; right adrenal gland; ; left adrenal cortex; ; gallbladder; ; upper lobe of lung; ; upper lobe of left lung;
	Top expressed in
	left lobe of liver; ; lacrimal gland; ; human fetus; ; yolk sac; ; gallbladder; ; fetal liver hematopoietic progenitor cell; ; parotid gland; ; abdominal wall; ; sexually immature organism; ; primitive streak;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein-macromolecule adaptor activity; structural molecule activity; metal ion binding; protein binding; signaling receptor binding; cell adhesion molecule binding; protein homodimerization activity; extracellular matrix structural constituent;
Cellular component	cytoplasm; platelet alpha granule; blood microparticle; plasma membrane; fibrinogen complex; extracellular region; cell surface; extracellular exosome; platelet alpha granule lumen; external side of plasma membrane; extracellular space; endoplasmic reticulum lumen; collagen-containing extracellular matrix;
Biological process	hemostasis; negative regulation of endothelial cell apoptotic process; positive regulation of peptide hormone secretion; protein polymerization; positive regulation of heterotypic cell-cell adhesion; fibrinolysis; platelet degranulation; blood coagulation; extracellular matrix organization; protein secretion; response to calcium ion; positive regulation of substrate adhesion-dependent cell spreading; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; positive regulation of vasoconstriction; positive regulation of protein secretion; positive regulation of ERK1 and ERK2 cascade; positive regulation of exocytosis; blood coagulation, fibrin clot formation; plasminogen activation; cell-matrix adhesion; platelet aggregation; signal transduction; platelet activation; toll-like receptor signaling pathway; platelet maturation; cellular response to interleukin-1; cellular response to interleukin-6; negative regulation of platelet aggregation; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	2266
	99571
	ENSG00000171557
	ENSMUSG00000033860
	P02679
	Q8VCM7
	NM_021870; NM_000509
	NM_133862; NM_001317105
	NP_000500; NP_068656
	NP_001304034; NP_598623
	Wikidata
View/Edit Human	View/Edit Mouse

Fibrinogen gamma chain, also known as the fibrinogen gamma gene (FGG), is a human gene found on chromosome 3.^[5]

AliasesFGG, fibrinogen gamma chain

External IDsOMIM: 134850; MGI: 95526; HomoloGene: 429; GeneCards: FGG; OMA:FGG - orthologs

PDBOrtholog search: PDBe RCSB

Chr.Chromosome 4 (human)^[1]

Quick facts FGG, Identifiers ...

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The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein composed of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia.^[6] Alternative splicing of the mRNA chain results in two transcript variants; the common γA chain and the alternatively spliced γ' chain. Approximately 10% of the total plasma fibrinogen consists of γA/γ' fibrinogen, with <1% consisting of γ'/γ' fibrinogen. Increased and decreased levels of γA/γ' fibrinogen have been associated with coronary artery disease and deep vein thrombosis respectively. In the lung parenchyma of smokers, upregulation of FGG transcript levels has been reported. ^[7]

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Fibrinogen gamma chain

References

Further reading

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