Fic/DOC protein family
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| Fic/DOC family | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 structure of cell filamentation protein (fic) from helicobacter pylori | |||||||||
| Identifiers | |||||||||
| Symbol | Fic | ||||||||
| Pfam | PF02661 | ||||||||
| InterPro | IPR003812 | ||||||||
| |||||||||
In molecular biology, the Fic/DOC protein family is a family of proteins which catalyzes the post-translational modification of proteins using phosphate-containing compound as a substrate.[1] Fic domain proteins typically use ATP as a co-factor, but in some cases GTP or UTP is used.[2] Post-translational modification performed by Fic domains is usually NMPylation (AMPylation, GMPylation or UMPylation), however they also catalyze phosphorylation and phosphocholine transfer.[2] This family contains a central conserved motif HPFX[D/E]GNGR in most members and it carries the invariant catalytic histidine.[1] Fic domain was found in bacteria, eukaryotes and archaea and can be found organized in almost hundred different multi-domain assemblies.[1]