Fluorometholone

Fluorometholone (INN, BAN, JAN) (brand names Efflumidex, Flucon, FML Forte, FML, others), also known as 6α-methyl-9α-fluoro-11β,17α-dihydroxypregna-1,4-diene-3,20-dione, is a synthetic glucocorticoid which is used in the treatment of inflammatory eye diseases.^[2][3][4] The C17α acetate ester, fluorometholone acetate (brand name Flarex), is also a glucocorticoid and is used for similar indications.^[2][3][4]

Other names(6S,8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one

AHFS/Drugs.comMonograph

MedlinePlusa682660

ATC code

• C05AA06 (WHO) D07AB06 (WHO), D07XB04 (WHO) (combinations), D10AA01 (WHO), S01BA07 (WHO)

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Fluorometholone

Clinical data
Other names	(6S,8S,9R,10S,11S,13S,14S,17R)-17-acetyl-9-fluoro-11,17-dihydroxy-6,10,13-trimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
AHFS/Drugs.com	Monograph
MedlinePlus	a682660
ATC code	C05AA06 (WHO) D07AB06 (WHO), D07XB04 (WHO) (combinations), D10AA01 (WHO), S01BA07 (WHO)
Legal status
Legal status	CA: ℞-only[1]
Identifiers
IUPAC name (1R,2S,8S,10S,11S,14R,15S,17S)-14-acetyl-1-fluoro-14,17-dihydroxy-2,8,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-dien-5-one
CAS Number	426-13-1 Y
PubChem CID	9878
IUPHAR/BPS	7079
DrugBank	DB00324 Y
ChemSpider	9494 Y
UNII	SV0CSG527L
KEGG	D01367 Y
ChEBI	CHEBI:31625 N
ChEMBL	ChEMBL1200600 N
CompTox Dashboard (EPA)	DTXSID7047435
ECHA InfoCard	100.006.402
Chemical and physical data
Formula	C22H29FO4
Molar mass	376.468 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(C)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)[C@@H](C)C[C@H]4[C@@H]2CC3)C)C
InChI InChI=1S/C22H29FO4/c1-12-9-17-15-6-8-21(27,13(2)24)20(15,4)11-18(26)22(17,23)19(3)7-5-14(25)10-16(12)19/h5,7,10,12,15,17-18,26-27H,6,8-9,11H2,1-4H3/t12-,15-,17-,18-,19-,20-,21-,22-/m0/s1 Y Key:FAOZLTXFLGPHNG-KNAQIMQKSA-N Y
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