FLOT1

Flotillin-1 is a protein that in humans is encoded by the FLOT1 gene.^[5]

AliasesFLOT1, flotillin 1

External IDsOMIM: 606998; MGI: 1100500; HomoloGene: 31337; GeneCards: FLOT1; OMA:FLOT1 - orthologs

Chr.Chromosome 6 (human)^[1]

End30,742,732 bp^[1]

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FLOT1
Identifiers
Aliases	FLOT1, flotillin 1
External IDs	OMIM: 606998; MGI: 1100500; HomoloGene: 31337; GeneCards: FLOT1; OMA:FLOT1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.33 Start 30,727,709 bp[1] End 30,742,732 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 B1 Start 36,134,122 bp[2] End 36,143,683 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal gland left adrenal gland left adrenal cortex right adrenal cortex apex of heart blood C1 segment dorsolateral prefrontal cortex left ventricle cerebellum Top expressed in granulocyte interventricular septum cardiac muscle tissue of left ventricle right ventricle dentate gyrus of hippocampal formation granule cell ankle joint sciatic nerve facial motor nucleus spinal ganglia visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protease binding protein binding protein heterodimerization activity ionotropic glutamate receptor binding Cellular component integral component of membrane endosome membrane cell-cell contact zone focal adhesion plasma membrane raft melanosome plasma membrane centriolar satellite microtubule organizing center lysosomal membrane flotillin complex uropod basolateral plasma membrane early endosome apical plasma membrane cortical actin cytoskeleton caveola membrane raft COP9 signalosome sarcolemma extracellular exosome cytoplasmic vesicle lamellipodium cell-cell junction external side of plasma membrane synapse presynaptic active zone dopaminergic synapse presynapse glutamatergic synapse GABA-ergic synapse Biological process positive regulation of cell-cell adhesion mediated by cadherin positive regulation of cell adhesion molecule production positive regulation of protein phosphorylation regulation of toll-like receptor 4 signaling pathway positive regulation of heterotypic cell-cell adhesion positive regulation of toll-like receptor 3 signaling pathway axonogenesis positive regulation of skeletal muscle tissue development positive regulation of cytokine production extracellular matrix disassembly protein kinase C signaling response to endoplasmic reticulum stress positive regulation of myoblast fusion positive regulation of endocytosis positive regulation of cell junction assembly protein localization to membrane raft membrane raft assembly cellular response to exogenous dsRNA regulation of receptor internalization positive regulation of synaptic transmission, dopaminergic positive regulation of protein binding regulation of Rho protein signal transduction protein homooligomerization dsRNA transport plasma membrane raft assembly positive regulation of interferon-beta production protein stabilization protein localization to plasma membrane regulation of neurotransmitter uptake positive regulation of NF-kappaB transcription factor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10211 14251 Ensembl ENSG00000137312 ENSG00000232280 ENSG00000224740 ENSG00000206480 ENSG00000206379 ENSG00000230143 ENSG00000236271 ENSG00000223654 ENSMUSG00000059714 UniProt O75955 O08917 RefSeq (mRNA) NM_005803 NM_001318875 NM_008027 RefSeq (protein) NP_001305804 NP_005794 NP_032053 Location (UCSC) Chr 6: 30.73 – 30.74 Mb Chr 17: 36.13 – 36.14 Mb PubMed search [3] [4]
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Caveolae are small domains on the inner cell membrane involved in vesicular trafficking and signal transduction. FLOT1 encodes a caveolae-associated, integral membrane protein.^[6] The function of flotillin 1 has not been determined.^[5]