The younger son of W. A. Hoghton, ICS, Frederick Hoghton was commissioned into the East Yorkshire Regiment in 1883. He transferred to the Indian Army in 1887 (Bombay Staff Corps) and served for many years with the 1st Bombay Grenadiers. He subsequently served as second-in-command of the 74th Punjabis and commanded the 69th Punjabis.
In 1915, he was appointed president of the Court of Inquiry investigating the mutiny in Singapore. He was then given command of the 17th (Ahmednagar) Brigade, under the 6th Indian Division. The division was cut off by the Ottoman forces at Kut in December 1915, when the Siege of Kut began. The food situation in Kut rapidly deteriorated, and men began to consume vegetation, which in turn led to many cases of poisoning. On the night of 11/12 April 1916, Hoghton, who had been in poor health, died of poisoning from consuming herbs which had been gathered locally.
He is buried at Kut War Cemetery, Iraq.