Growth-hormone-releasing hormone receptor

GHRHR
Identifiers
Aliases	GHRHR, GHRFR, GRFR, IGHD1B, growth hormone releasing hormone receptor, IGHD4
External IDs	OMIM: 139191; MGI: 95710; GeneCards: GHRHR
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2XDG
Gene location (Human)
Chr.	Chromosome 7 (human)
End	30,993,254 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	55,365,515 bp
RNA expression pattern
	Top expressed in
	pituitary gland; ; anterior pituitary; ; oocyte; ; secondary oocyte; ; hypothalamus; ; cingulate gyrus; ; anterior cingulate cortex; ; amygdala; ; Descending thoracic aorta; ; nucleus accumbens;
	Top expressed in
	pituitary gland; ; anterior pituitary; ; choroid plexus of fourth ventricle; ; entorhinal cortex; ; CA3 field; ; soleus muscle; ; proximal tubule; ; right kidney; ; yolk sac; ; tibialis anterior muscle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; growth factor binding; signal transducer activity; peptide hormone binding; protein binding; growth hormone-releasing hormone receptor activity; transmembrane signaling receptor activity; G protein-coupled peptide receptor activity;
Cellular component	cytoplasm; integral component of membrane; membrane; nuclear matrix; plasma membrane; secretory granule; cell surface; nuclear inner membrane; sarcolemma; nuclear outer membrane;
Biological process	adenylate cyclase-activating G protein-coupled receptor signaling pathway; determination of adult lifespan; adenylate cyclase-modulating G protein-coupled receptor signaling pathway; response to glucocorticoid; cell maturation; adenohypophysis development; water homeostasis; activation of adenylate cyclase activity; response to estrogen; mammary gland development; response to insulin; positive regulation of circadian sleep/wake cycle, non-REM sleep; cell surface receptor signaling pathway; regulation of insulin-like growth factor receptor signaling pathway; positive regulation of insulin-like growth factor receptor signaling pathway; growth hormone secretion; positive regulation of growth hormone secretion; positive regulation of cell population proliferation; positive regulation of multicellular organism growth; cellular response to insulin stimulus; somatotropin secreting cell development; regulation of protein metabolic process; lactation; regulation of intracellular steroid hormone receptor signaling pathway; hormone metabolic process; positive regulation of hormone secretion; cAMP-mediated signaling; cellular response to glucose stimulus; signal transduction; multicellular organismal reproductive process; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	2692
	14602
	ENSG00000106128
	ENSMUSG00000004654
	Q02643
	P32082
	NM_000823; NM_001009824
	NM_001003685
	NP_000814
	NP_001003685
	Wikidata
View/Edit Human	View/Edit Mouse

The growth-hormone-releasing hormone receptor (GHRHR) is a G-protein-coupled receptor that binds growth hormone-releasing hormone. The GHRHR activates a Gs protein that causes a cascade of cAMP via adenylate cyclase.^[5] GHRHR is distinct from the growth hormone secretagogue receptor (also known as the ghrelin receptor), where growth hormone-releasing peptides act to release growth hormone.