Glypican 4

Glypican-4 is a protein that in humans is encoded by the GPC4 gene.^[5][6]

AliasesGPC4, K-glypican, glypican 4, KPTS

External IDsOMIM: 300168; MGI: 104902; HomoloGene: 55582; GeneCards: GPC4; OMA:GPC4 - orthologs

Chr.X chromosome (human)^[1]

End133,415,489 bp^[1]

Quick facts GPC4, Identifiers ...

GPC4
Identifiers
Aliases	GPC4, K-glypican, glypican 4, KPTS
External IDs	OMIM: 300168; MGI: 104902; HomoloGene: 55582; GeneCards: GPC4; OMA:GPC4 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq26.2 Start 133,300,103 bp[1] End 133,415,489 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X A5|X 28.33 cM Start 51,141,898 bp[2] End 51,254,129 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence gastric mucosa right lung thoracic aorta ascending aorta popliteal artery tibial arteries Descending thoracic aorta muscle layer of sigmoid colon Top expressed in stroma of bone marrow cumulus cell ascending aorta human kidney right kidney calvaria aortic valve molar ciliary body ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function heparan sulfate proteoglycan binding coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway Cellular component membrane plasma membrane integral component of plasma membrane extracellular region lysosomal lumen Golgi lumen anchored component of membrane extracellular exosome external side of plasma membrane nucleus extracellular space synapse anchored component of plasma membrane collagen-containing extracellular matrix glutamatergic synapse anchored component of presynaptic membrane cell surface Biological process glycosaminoglycan metabolic process anatomical structure morphogenesis retinoid metabolic process glycosaminoglycan catabolic process glycosaminoglycan biosynthetic process cell population proliferation Wnt signaling pathway, planar cell polarity pathway regulation of signal transduction regulation of neurotransmitter receptor localization to postsynaptic specialization membrane synaptic membrane adhesion regulation of presynapse assembly cell migration regulation of protein localization to membrane Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2239 14735 Ensembl ENSG00000076716 ENSMUSG00000031119 UniProt O75487 P51655 RefSeq (mRNA) NM_001448 NM_008150 RefSeq (protein) NP_001439 NP_032176 Location (UCSC) Chr X: 133.3 – 133.42 Mb Chr X: 51.14 – 51.25 Mb PubMed search [3] [4]
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Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The GPC4 gene is adjacent to the 3' end of GPC3 and may also play a role in Simpson-Golabi-Behmel syndrome.^[6]