Glycine/sarcosine N-methyltransferase
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Glycine/sarcosine N-methyltransferase (EC 2.1.1.156, ApGSMT, glycine-sarcosine methyltransferase, GSMT, GMT, glycine sarcosine N-methyltransferase, S-adenosyl-L-methionine:sarcosine N-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:glycine(or sarcosine) N-methyltransferase (sarcosine(or N,N-dimethylglycine)-forming).[1][2] It catalyses the following overall chemical reaction
| Glycine/sarcosine N-methyltransferase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.1.1.156 | ||||||||
| CAS no. | 294210-82-5 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
The enzyme adds two methyl groups, with the intermediate, sarcosine, being methylated again to give the product N,N-dimethyl glycine. The methyl groups come from the cofactor, S-adenosyl methionine (SAM), which becomes S-adenosyl-L-homocysteine (SAH). The enzyme was characterised from the cyanobacterium, Aphanothece halophytica. N,N-dimethyl glycine is subsequently converted to betaine by the enzyme sarcosine/dimethylglycine N-methyltransferase.[3][4]
