Lumiliximab
Monoclonal antibody
From Wikipedia, the free encyclopedia
Lumiliximab is an IgG1k monoclonal antibody that targets CD23. It acts as an immunomodulator[1] and was awarded orphan drug status and fast track designation by the FDA.[2]
| Monoclonal antibody | |
|---|---|
| Type | Whole antibody |
| Source | Chimeric (primate/human) |
| Target | CD23 |
| Clinical data | |
| ATC code |
|
| Identifiers | |
| CAS Number | |
| DrugBank | |
| ChemSpider |
|
| UNII | |
| Chemical and physical data | |
| Formula | C2115H3252N556O673S16 |
| Molar mass | 47749.46 g·mol−1 |
  (what is this?) (verify) | |
It was investigated in Phase II/III clinical trials for the treatment of chronic lymphocytic leukemia.[3][4] It has also been studied for use in allergic asthma. The drug is a chimeric antibody from Macaca irus and Homo sapiens.[1]
Lumiliximab was developed by IDEC Pharmaceuticals, which was acquired by Biogen. Clinical trials for CLL were terminated in 2010, and for allergic asthma in 2007.[2] Results published from the CLL clinical trial failed to meet primary endpoints.[5]
