H1FX

Histone H1x is a protein that in humans is encoded by the H1FX gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesH1-10, H1X, H1.10, H1 histone family member X, H1FX, H1.10 linker histone

External IDsOMIM: 602785; MGI: 2685307; HomoloGene: 4397; GeneCards: H1-10; OMA:H1-10 - orthologs

Chr.Chromosome 3 (human)^[1]

Quick facts H1-10, Available structures ...

H1-10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LSO
Identifiers
Aliases	H1-10, H1X, H1.10, H1 histone family member X, H1FX, H1.10 linker histone
External IDs	OMIM: 602785; MGI: 2685307; HomoloGene: 4397; GeneCards: H1-10; OMA:H1-10 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q21.3 Start 129,314,771 bp[1] End 129,316,286 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 D1 Start 87,957,403 bp[2] End 87,958,619 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence olfactory zone of nasal mucosa thymus ectocervix right ovary skin of abdomen right uterine tube left ovary left uterine tube Top expressed in ventricular zone adrenal medulla ganglionic eminence white adipose tissue striatum of neuraxis lens testicle neural tube primary visual cortex superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding RNA binding cadherin binding double-stranded DNA binding protein binding nucleosomal DNA binding Cellular component nucleosome nucleolus nucleus chromosome Biological process nucleosome assembly regulation of transcription, DNA-templated chromosome condensation negative regulation of DNA recombination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8971 243529 Ensembl ENSG00000184897 ENSMUSG00000044927 UniProt Q92522 Q80ZM5 RefSeq (mRNA) NM_006026 NM_198622 RefSeq (protein) NP_006017 NP_941024 Location (UCSC) Chr 3: 129.31 – 129.32 Mb Chr 6: 87.96 – 87.96 Mb PubMed search [3] [4]
Wikidata
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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H1 family.^[7]