HIST1H2AB

Histone H2A type 1-B/E is a protein that in humans is encoded by the HIST1H2AB gene.^[5][6][7][8]

PDBOrtholog search: PDBe RCSB

AliasesH2AC4, H2A/m, H2AFM, histone cluster 1, H2ab, histone cluster 1 H2A family member b, HIST1H2AB, H2A clustered histone 4, H2AC8

External IDsOMIM: 602795; MGI: 2448293; HomoloGene: 135982; GeneCards: H2AC4; OMA:H2AC4 - orthologs

Chr.Chromosome 6 (human)^[1]

Quick facts H2AC4, Available structures ...

H2AC4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CV5, 3A6N, 3AFA, 3AN2, 3AV1, 3AV2, 3AYW, 3AZE, 3AZF, 3AZG, 3AZH, 3AZI, 3AZJ, 3AZK, 3AZL, 3AZM, 3AZN, 3W96, 3W97, 3W98, 3W99, 3WKJ, 3WTP, 5CPJ, 5B0Z, 4YM5, 5AV9, 5AVB, 5AV5, 4YM6, 5CPI, 3X1V, 5AV6, 3X1S, 5AV8, 5CPK, 5AVC, 5B0Y, 4Z5T, 5B24, 2RVQ, 5B40, 5AY8, 5B2I, 5B2J
Identifiers
Aliases	H2AC4, H2A/m, H2AFM, histone cluster 1, H2ab, histone cluster 1 H2A family member b, HIST1H2AB, H2A clustered histone 4, H2AC8
External IDs	OMIM: 602795; MGI: 2448293; HomoloGene: 135982; GeneCards: H2AC4; OMA:H2AC4 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.2 Start 26,033,092 bp[1] End 26,033,618 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.1 Start 22,226,630 bp[2] End 22,227,114 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cell testicle epithelium of colon Achilles tendon buccal mucosa cell gonad granulocyte ventricular zone tonsil ganglionic eminence Top expressed in spermatid embryo uterus embryo zygote mesencephalon spermatocyte secondary oocyte primary oocyte neural tube More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein heterodimerization activity protein binding Cellular component nucleosome extracellular exosome nucleus chromosome Biological process negative regulation of cell population proliferation chromatin organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8335 319167 Ensembl ENSG00000278463 ENSMUSG00000069301 UniProt P04908 C0HKE2 B2RVF0 C0HKE1 C0HKE3 C0HKE4 C0HKE5 C0HKE6 C0HKE7 C0HKE8 C0HKE9 RefSeq (mRNA) NM_003513 NM_178186 RefSeq (protein) NP_003504 NP_835496 NP_835495 NP_835494 NP_835491 NP_835489 NP_783591 NP_835493 NP_835496 NP_835489 NP_835495 NP_835494 NP_835491 NP_835492 NP_783591 NP_001171015 NP_835489 NP_001171015 NP_835496 NP_835491 NP_835493 NP_835494 NP_835495 NP_835492 NP_783591 NP_835494 NP_835489 NP_835495 NP_835491 NP_835492 NP_783591 NP_001171015 NP_835493 NP_835496 NP_835495 NP_835489 NP_835494 NP_835491 NP_835492 NP_783591 NP_001171015 NP_835493 NP_835496 NP_835492 NP_835491 NP_835489 NP_835495 NP_835494 NP_783591 NP_001171015 NP_835493 NP_835496 NP_835491 NP_835489 NP_835495 NP_835494 NP_835492 NP_783591 NP_001171015 NP_835493 NP_835496 NP_783591 NP_835489 NP_835495 NP_835494 NP_835491 NP_835492 NP_001171015 NP_835493 NP_835496 NP_783591 NP_835489 NP_835495 NP_835494 NP_835491 NP_835492 NP_001171015 NP_835493 NP_835496 Location (UCSC) Chr 6: 26.03 – 26.03 Mb Chr 13: 22.23 – 22.23 Mb PubMed search [3] [4]
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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.^[8]