HIST1H2BJ

Histone H2B type 1-J is a protein that in humans is encoded by the HIST1H2BJ gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesH2BC11, H2B/r, H2BFR, H2BJ, histone cluster 1, H2bj, histone cluster 1 H2B family member j, H2B clustered histone 11, HIST1H2BJ

External IDsOMIM: 615044; MGI: 2448415; HomoloGene: 128594; GeneCards: H2BC11; OMA:H2BC11 - orthologs

Chr.Chromosome 6 (human)^[1]

Quick facts H2BC11, Available structures ...

H2BC11
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3A6N, 3AFA, 3AN2, 3AV1, 3AV2, 3AYW, 3AZE, 3AZF, 3AZG, 3AZH, 3AZI, 3AZJ, 3AZK, 3AZL, 3AZM, 3AZN, 3W96, 3W97, 3W98, 3W99, 3WA9, 3WAA, 3WTP, 4CAY, 5CPJ, 5B0Z, 4YM5, 5AV9, 5AVB, 5AV5, 4YM6, 5CPI, 5AV6, 5AV8, 5CPK, 5AVC, 5B0Y, 4Z5T, 5FUG, 5B24, 2RVQ, 5AY8, 5B2I, 5B40, 5B2J
Identifiers
Aliases	H2BC11, H2B/r, H2BFR, H2BJ, histone cluster 1, H2bj, histone cluster 1 H2B family member j, H2B clustered histone 11, HIST1H2BJ
External IDs	OMIM: 615044; MGI: 2448415; HomoloGene: 128594; GeneCards: H2BC11; OMA:H2BC11 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.1 Start 27,125,897 bp[1] End 27,132,795 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.1 Start 96,128,435 bp[2] End 96,131,054 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cell monocyte testicle Achilles tendon gonad left testis right testis blood granulocyte corpus callosum Top expressed in olfactory epithelium otolith organ utricle ciliary body iris vestibular membrane of cochlear duct conjunctival fornix pineal gland ascending aorta Paneth cell More reference expression data BioGPS n/a
Gene ontology Molecular function protein heterodimerization activity DNA binding lipopolysaccharide binding protein binding Cellular component nucleosome nucleus chromosome nucleoplasm extracellular space cytosol plasma membrane Biological process nucleosome assembly innate immune response in mucosa defense response to bacterium protein ubiquitination negative regulation of tumor necrosis factor-mediated signaling pathway antimicrobial humoral immune response mediated by antimicrobial peptide Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8970 319190 Ensembl ENSG00000124635 ENSMUSG00000068854 UniProt P06899 Q64524 RefSeq (mRNA) NM_021058 NM_178214 RefSeq (protein) NP_066402 NP_835586 Location (UCSC) Chr 6: 27.13 – 27.13 Mb Chr 3: 96.13 – 96.13 Mb PubMed search [3] [4]
Wikidata
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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33.^[7]