HIST1H2BL

Histone H2B type 1-L is a protein that in humans is encoded by the HIST1H2BL gene.^[5][6][7]

AliasesH2BC13, H2B/c, H2BFC, dJ97D16.4, histone cluster 1, H2bl, histone cluster 1 H2B family member l, H2B clustered histone 13, HIST1H2BL

External IDsOMIM: 602800; MGI: 2448388; HomoloGene: 136771; GeneCards: H2BC13; OMA:H2BC13 - orthologs

Chr.Chromosome 6 (human)^[1]

End27,807,929 bp^[1]

Quick facts H2BC13, Identifiers ...

H2BC13
Identifiers
Aliases	H2BC13, H2B/c, H2BFC, dJ97D16.4, histone cluster 1, H2bl, histone cluster 1 H2B family member l, H2B clustered histone 13, HIST1H2BL
External IDs	OMIM: 602800; MGI: 2448388; HomoloGene: 136771; GeneCards: H2BC13; OMA:H2BC13 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.1 Start 27,807,479 bp[1] End 27,807,929 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.1 Start 22,227,384 bp[2] End 22,227,846 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cell testicle Achilles tendon epithelium of colon gonad monocyte tonsil granulocyte mucosa of transverse colon ganglionic eminence Top expressed in zygote secondary oocyte primary oocyte uterus bone marrow spermatid genital tubercle embryo embryo spermatocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein heterodimerization activity DNA binding Cellular component nucleosome nucleus chromosome extracellular exosome nucleoplasm cytosol Biological process nucleosome assembly protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8340 319183 Ensembl ENSG00000185130 ENSMUSG00000069300 UniProt Q99880 P10853 RefSeq (mRNA) NM_003519 NM_178198 RefSeq (protein) NP_003510 NP_835505 NP_001091448 NP_001300809 NP_001104025 NP_001300807 NP_835502 NP_835506 NP_835508 Location (UCSC) Chr 6: 27.81 – 27.81 Mb Chr 13: 22.23 – 22.23 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Close

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.^[7]