HIST1H2BM

Histone H2B type 1-M is a protein that in humans is encoded by the HIST1H2BM gene.^[5][6][7]

AliasesH2BC14, H2B/e, H2BFE, dJ160A22.3, histone cluster 1, H2bm, histone cluster 1 H2B family member m, HIST1H2BM, H2B clustered histone 14

External IDsOMIM: 602802; MGI: 2448407; HomoloGene: 136772; GeneCards: H2BC14; OMA:H2BC14 - orthologs

Chr.Chromosome 6 (human)^[1]

End27,815,489 bp^[1]

Quick facts H2BC14, Identifiers ...

H2BC14
Identifiers
Aliases	H2BC14, H2B/e, H2BFE, dJ160A22.3, histone cluster 1, H2bm, histone cluster 1 H2B family member m, HIST1H2BM, H2B clustered histone 14
External IDs	OMIM: 602802; MGI: 2448407; HomoloGene: 136772; GeneCards: H2BC14; OMA:H2BC14 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.1 Start 27,815,022 bp[1] End 27,815,489 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.1 Start 21,938,293 bp[2] End 21,938,673 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cell ventricular zone epithelium of colon tonsil thymus ganglionic eminence mucosa of transverse colon blood lymph node corpus callosum Top expressed in genital tubercle uterus spermatid bone marrow embryo embryo spermatocyte primary oocyte tail of embryo thymus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein heterodimerization activity DNA binding Cellular component nucleosome nucleus chromosome extracellular exosome nucleoplasm cytosol Biological process nucleosome assembly protein ubiquitination Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8342 319187 Ensembl ENSG00000273703 ENSMUSG00000095217 UniProt Q99879 P10853 RefSeq (mRNA) NM_003521 NM_178201 RefSeq (protein) NP_003512 NP_835505 NP_001091448 NP_001300809 NP_001104025 NP_001300807 NP_835502 NP_835506 NP_835508 Location (UCSC) Chr 6: 27.82 – 27.82 Mb Chr 13: 21.94 – 21.94 Mb PubMed search [3] [4]
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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.^[7]