HIST3H2BB

Histone H2B type 3-B is a protein that in humans is encoded by the HIST3H2BB gene.^[5][6]

AliasesH2BU1, H2Bb, histone cluster 3, H2bb, histone cluster 3 H2B family member b, H2B.U histone 1, HIST3H2BB

External IDsOMIM: 615046; MGI: 1922442; HomoloGene: 75941; GeneCards: H2BU1; OMA:H2BU1 - orthologs

Chr.Chromosome 1 (human)^[1]

End228,463,104 bp^[1]

Quick facts H2BU1, Identifiers ...

H2BU1
Identifiers
Aliases	H2BU1, H2Bb, histone cluster 3, H2bb, histone cluster 3 H2B family member b, H2B.U histone 1, HIST3H2BB
External IDs	OMIM: 615046; MGI: 1922442; HomoloGene: 75941; GeneCards: H2BU1; OMA:H2BU1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.13 Start 228,458,103 bp[1] End 228,463,104 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.3 Start 58,844,874 bp[2] End 58,845,254 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cell right uterine tube cerebellum cerebellar hemisphere right hemisphere of cerebellum ganglionic eminence ventricular zone olfactory zone of nasal mucosa gonad prefrontal cortex Top expressed in ganglionic eminence spermatocyte epiblast dentate gyrus of hippocampal formation granule cell ventricular zone embryo mesencephalon lens neural tube proximal tubule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding protein heterodimerization activity molecular function Cellular component chromosome nucleosome nucleus nucleoplasm cytosol Biological process nucleosome assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 128312 382522 Ensembl ENSG00000196890 ENSG00000285449 ENSMUSG00000080712 UniProt Q8N257 n/a RefSeq (mRNA) NM_175055 NM_001393523 RefSeq (protein) NP_778225 n/a Location (UCSC) Chr 1: 228.46 – 228.46 Mb Chr 11: 58.84 – 58.85 Mb PubMed search [3] [4]
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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 base pairs (bp) of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene contain a palindromic termination element.^[6]