HIST1H2BG

Histone H2B type 1-C/E/F/G/I is a protein that in humans is encoded by the HIST1H2BG gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesH2BC8, H2B.1A, H2B/a, H2BFA, dJ221C16.8, histone cluster 1, H2bg, histone cluster 1 H2B family member g, HIST1H2BG, H2B clustered histone 8, H2BC10, H2BC7, H2BC6, H2BC4

External IDsOMIM: 602798; MGI: 2448383; HomoloGene: 136770; GeneCards: H2BC8; OMA:H2BC8 - orthologs

Chr.Chromosome 6 (human)^[1]

Quick facts H2BC8, Available structures ...

H2BC8
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5KGF
Identifiers
Aliases	H2BC8, H2B.1A, H2B/a, H2BFA, dJ221C16.8, histone cluster 1, H2bg, histone cluster 1 H2B family member g, HIST1H2BG, H2B clustered histone 8, H2BC10, H2BC7, H2BC6, H2BC4
External IDs	OMIM: 602798; MGI: 2448383; HomoloGene: 136770; GeneCards: H2BC8; OMA:H2BC8 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.2 Start 26,216,200 bp[1] End 26,216,688 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.1 Start 23,757,910 bp[2] End 23,758,370 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell thymus corpus epididymis bone marrow cell gonad amniotic fluid monocyte testicle caput epididymis epithelium of colon Top expressed in uterus blastocyst genital tubercle tail of embryo embryo embryo spermatocyte yolk sac zygote thymus More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein binding protein heterodimerization activity identical protein binding Cellular component chromosome nucleosome extracellular exosome nucleus nucleoplasm extracellular space cytosol Biological process nucleosome assembly innate immune response in mucosa defense response to bacterium protein ubiquitination antimicrobial humoral immune response mediated by antimicrobial peptide Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8339 319180 Ensembl ENSG00000273802 ENSMUSG00000069268 UniProt P62807 P10853 RefSeq (mRNA) NM_003518 NM_178195 RefSeq (protein) NP_003517 NP_001368918 NP_835505 NP_001091448 NP_001300809 NP_001104025 NP_001300807 NP_835502 NP_835506 NP_835508 Location (UCSC) Chr 6: 26.22 – 26.22 Mb Chr 13: 23.76 – 23.76 Mb PubMed search [3] [4]
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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2B family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3.^[7]