HIST1H3D

Histone H3.1 is a protein that in humans is encoded by the HIST1H3D gene.^[5][6][7]

PDBOrtholog search: PDBe RCSB

AliasesH3C4, H3/b, H3FB, histone cluster 1, H3d, histone cluster 1 H3 family member d, HIST1H3D, H3 clustered histone 4, H3C7, H3C12, H3C2, H3C8, H3C10, H3C3, H3C1, H3C11, H3C6

External IDsOMIM: 602811; MGI: 2668828; HomoloGene: 134487; GeneCards: H3C4; OMA:H3C4 - orthologs

Chr.Chromosome 6 (human)^[1]

Quick facts H3C4, Available structures ...

H3C4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3WKJ, 3B95, 2C1J, 3AYW, 3WA9, 3U4S, 5AVB, 2CV5, 5AV5, 3U31, 2UXN, 3AZK, 2C1N, 5C11, 3QO2, 3X1V, 5C13, 4A0J, 4U68, 5AV8, 4LLB, 3U5O, 1O9S, 4FT2, 4HON, 3W99, 3ZVY, 4Z0R, 5AVC, 1CT6, 1Q3L, 3O37, 3W97, 3SOW, 3KMT, 4YM6, 4A7J, 3UEE, 2KWK, 4F4U, 3UEF, 3UIG, 4BD3, 3AZL, 4QBR, 4F56, 3AFA, 4LKA, 5CPK, 5FFV, 3V43, 5CH1, 3U5P, 3AZI, 3U5N, 3AZH, 3UIK, 4QBQ, 1U35, 4UY4, 2OT7, 5AV9, 2B2W, 3U3D, 3AZF, 3W98, 4I51, 4X3K, 4FWF, 2B2T, 2B2V, 4A0N, 2KWJ, 3WAA, 3QJ6, 5DAH, 3AZG, 3AZE, 3X1T, 3RIY, 2L75, 3A1B, 2VPG, 4QBS, 3O35, 5CPJ, 3ZG6, 4YM5, 3AZJ, 2RI7, 3AZN, 3AVR, 5CPI, 2LBM, 3W96, 3O34, 2M0O, 4L7X, 5CH2, 5AV6, 3AZM, 4UP0, 3X1S, 2OX0, 3UII, 3SOU, 4N4H, 4TN7, 1CS9, 3X1U, 4LXL, 2B2U, 2OQ6, 3RIG, 5C3I, 4YHP, 5B24, 5D6Y, 4YHZ, 4Z2M, 5HJD, 5HJC, 5HJB, 5B2I, 5HYN, 5FB0, 5FB1, 5IQL, 5B2J, 5JIN
Identifiers
Aliases	H3C4, H3/b, H3FB, histone cluster 1, H3d, histone cluster 1 H3 family member d, HIST1H3D, H3 clustered histone 4, H3C7, H3C12, H3C2, H3C8, H3C10, H3C3, H3C1, H3C11, H3C6
External IDs	OMIM: 602811; MGI: 2668828; HomoloGene: 134487; GeneCards: H3C4; OMA:H3C4 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p22.2 Start 26,196,784 bp[1] End 26,197,286 bp[1]
Gene location (Mouse) Chr. Chromosome 13 (mouse)[2] Band 13|13 A3.1 Start 23,945,836 bp[2] End 23,946,369 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cell gonad testicle epithelium of colon tonsil Achilles tendon corpus callosum blood ventricular zone mucosa of transverse colon Top expressed in uterus spermatid bone marrow embryo zygote embryo spermatocyte secondary oocyte morula blastocyst More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding histone binding protein binding protein heterodimerization activity cadherin binding nucleosomal DNA binding Cellular component membrane nucleoplasm chromosome extracellular region nuclear chromosome extracellular exosome nucleosome nucleus protein-containing complex Biological process telomere organization epigenetic maintenance of chromatin in transcription-competent conformation protein heterotetramerization blood coagulation DNA replication-dependent chromatin assembly rDNA heterochromatin assembly negative regulation of gene expression, epigenetic chromatin organization regulation of gene silencing by miRNA nucleosome assembly interleukin-7-mediated signaling pathway regulation of megakaryocyte differentiation regulation of hematopoietic stem cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8351 360198 Ensembl ENSG00000197409 ENSMUSG00000069265 UniProt P68431 P68433 RefSeq (mRNA) NM_003530 NM_001376937 NM_013550 RefSeq (protein) NP_066298 NP_003520 NP_003525 NP_003527 NP_835513 NP_835514 NP_659539 Location (UCSC) Chr 6: 26.2 – 26.2 Mb Chr 13: 23.95 – 23.95 Mb PubMed search [3] [4]
Wikidata
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Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H3 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.^[7]