Haplogroup R-M124
Human Y-chromosome DNA haplogroup
From Wikipedia, the free encyclopedia
Haplogroup R2a, or haplogroup R-M124, is a Y-chromosome haplogroup characterized by genetic markers M124, P249, P267, L266, and is mainly found in South Asia as well as in Central Asia, Caucasus, Middle East and North Africa.
| Haplogroup R2a | |
|---|---|
| Possible time of origin | 14,700 [95% CI 13,200 <-> 16,100] years before present[1] |
| Coalescence age | 11,900 [95% CI 10,500 <-> 13,400] years before present[1] |
| Possible place of origin | Southwest Asia |
| Ancestor | R-M479 |
| Descendants | R-M124*, R-L295, R-L263, R-L1069 |
| Defining mutations | M124, P249, P267, L266 [2][3] |
Term history
Haplogroup R2a is also known as haplogroup R-M124.[2] The first reference to the newly defined haplogroup, "R-M124", was on 25 August 2010.[4]
Before the publication of the 2005 Y-Chromosome Phylogenetic Tree, Haplogroup R-M124 was known as Haplogroup P1 and formerly thought to be a sister clade of Haplogroup R rather than derived from it.[5]
Haplogroup R2 most often observed in Asia, especially on the Indian subcontinent and Central Asia.[5] It is also reported at notable frequencies in the Caucasus.
Origins
According to Sengupta et al. (2006),
uncertainty neutralizes previous conclusions that the intrusion of HGs R1a1 and R2 [Now R-M124] from the northwest in Dravidian-speaking southern tribes is attributable to a single recent event. Rather, these HGs contain considerable demographic complexity, as implied by their high haplotype diversity. Specifically, they could have actually arrived in southern India from a southwestern Asian source region multiple times, with some episodes considerably earlier than others.
Subclades
| Haplogroup R‑M124 |
| ||||||||||||
Paragroup R-M124*
Paragroup is a term used in population genetics to describe lineages within a haplogroup that are not defined by any additional unique markers. They are typically represented by an asterisk (*) placed after the main haplogroup.
Y-chromosomes which are positive to the M124, P249, P267, and L266 SNPs and negative to the L295, L263, and L1069 SNPs, are categorized as belonging to Paragroup R-M124*. It is found in Iraq, so far.
Haplogroup R-L295
Haplogroup R-L295 is a Y-chromosome haplogroup characterized by genetic marker L295. It is found in South Asia, Anatolia, Arabian Peninsula, Europe, & Central Asia so far.
Haplogroup R-L263
Haplogroup R-L263 is a Y-chromosome haplogroup characterized by genetic marker L263. It is found in Greek Asia Minor & Armenia so far.[6]
Haplogroup R-L1069
Haplogroup R-L1069 is a Y-chromosome haplogroup characterized by genetic marker L1069. It is found in Kuwait so far.[6]
Distribution
R-M124 is most often observed in Asia, especially on the Indian subcontinent and in Central Asia[5] It is also reported at notable frequencies in Caucasus.
Historical
Ancient samples of haplogroup R2a were observed in the remains of humans from Neolithic, Chalcolithic and Bronze Age Iran and Turan; and Iron Age South Asia. R2a was also recovered from excavated remains in the South Asian sites of Saidu Sharif and Butkara from a later period.[7]
South Asia
| Tibeto-Burman | Austro-Asiatic | Dravidian | Indo-European | |
|---|---|---|---|---|
| Tribe | 5.75% | 10.94% | 5.00% | - |
| Lower Caste | - | - | 13.79% | 10.00% |
| Middle Caste | - | - | 3.53% | 18.75% |
| Upper Caste | - | - | 10.17% | 16.28% |
Haplogroup R-M124, along with haplogroups H, L, R1a1, and J2, forms the majority of the South Asian male population. The frequency is around 10-15% in India and Sri Lanka and 7-8% in Pakistan. Its spread within South Asia is very extensive, ranging from Balochistan in the west to Bengal in the east; Hunza in the north to Sri Lanka in the south.
India
Among regional groups, it is found among West Bengalis (23%), New Delhi Hindus (20%), Punjabis (5%) and Gujaratis (3%).[8] Among tribal groups, Karmalis of West Bengal showed highest at 100% (16/16)[9] followed by Lodhas (43%)[10] to the east, while Bhil of Gujarat in the west were at 18%,[11] Tharus of north showed it at 17%,[12] Chenchu and Pallan of south were at 20% and 14% respectively.[9][13] Among caste groups, high percentages are shown by Jaunpur Kshatriyas (87%), Kamma Chaudhary (73%), Bihar Yadav (50%), Khandayat (46%), and Kallar (44%).[9]
It is also significantly high in many Brahmin groups including Bhargavas (32%), Chaturvedis (32%), Lingayat Brahmins (30%), Punjabi Brahmins (25%), Bengali Brahmins (22%), Konkanastha Brahmins (20%), Tamil Brahmins (17%) and Kashmiri Pandits (14%).[11][14][12][9][15]
North Indian Muslims have a frequency of 19% (Sunni) and 13% (Shia),[14] while Dawoodi Bohra Muslim in the western state of Gujarat have a frequency of 16% and Mappila Muslims of South India have a frequency of 5%.[16]
Pakistan
The R2 haplogroup in the northern regions of Pakistan is found among Kalash people (33%), Burusho people (14%), Pashtuns (10%) and Hazaras (4%).[17][18][13]
In southern regions, it is found among Balochis (12%), Brahuis (12%) and Sindhis (5%).[13]
Afghanistan
The R2-M124 haplogroup occurs at a considerably higher rate in the northern regions of Afghanistan (11.4%).[19] Although the true percentage remains debated, the haplogroup is known to be at elevated levels in the Pamiri population (number ranges from 6-17% depending on the group). One study on Nuristanis shows a 20% frequency of R2 (1/5), albeit with a small sample size.[20]
Sri Lanka
38% of the Sinhalese of Sri Lanka were found to be R2 positive according to a 2003 research.[8]
Central Asia
In Kazakh tribes it varies from 1% to 12%, however it is found at a higher percent at about 25% among Tore Tribe / Genghis Khans descendant tribe.[21]
In Central Asia, Tajikistan shows Haplogroup R-M124 at 6%, while the other '-stan' states vary around 2%. Bartangis of Tajikistan have a high frequency of R-M124 at about 17%, Ishkashimi at 8%, Khojant at 9% and Dushanbe at 6%.
Specifically, Haplogroup R-M124 has been found in approximately 7.5% (4/53) of recent Iranian emigrants living in Samarkand,[22] 7.1% (7/99) of Pamiris,[22] 6.8% (3/44) of Karakalpaks,[22] 5.1% (4/78) of Tajiks,[22] 5% (2/40) of Dungans in Kyrgyzstan,[22] 3.3% (1/30) of Turkmens,[22] 2.2% (8/366) of Uzbeks,[22] and 1.9% (1/54) of Kazakhs.[22]
West Asia and North Africa
The haplogroup R-M124 frequency of 6.1% (6/114) was found among overall Kurds[23] while in one study which was done with 25 samples of Kurmanji Kurds from Georgia, R-M124 has been observed at 44% (11/25)[24]
In Caucasus high frequency was observed in Armenians from Sason at 17% (18/104)[25] while it was observed at %1 in Armenians from Van. R2 has been found in Chechens at 16%.[26][5] R-M124 has been found in approximately 8% (2/24) of a sample of Ossetians from Alagir.[27]
In the Caucasus, around 16% of Mountain Jews, 8% of Balkars,[28] 6% of Kalmyks,[29] 3% of Azerbaijanis,[26] 2.6% of Kumyks,[30] 2.4% of Avars,[30] 2% of Armenians,[26] and 1% to 6% of Georgians[26][28][31] belong to the R-M124 haplogroup. Approximately 1% of Turks[32] and 1% to 3% of Iranians[33] also belong to this haplogroup.
In Iran R-M124 follows a similar distribution as R1a1 with higher percentages in the southeastern Iran. It has been found at Frequencies of 9.1% at Isfahan, 6.9% at Hormozgan and 4.2% in Mazandaran.[34]
In the R2-M124-WTY and R-Arabia Y-DNA Projects,[6][35] Haplogroup R-M124 has appeared in the following Arab countries: Kuwait (3 clusters), United Arab Emirates (1 cluster), Syria (1 cluster), and Tunisia (1 cluster).
Thus, Haplogroup R-M124 has been observed among Arabs at low frequencies in 11 countries/territories (Egypt, Jordan, Kuwait, Lebanon, Palestine, Qatar, Syria, Tunisia, United Arab Emirates, and Yemen) of the 22 Arab countries/territories so far. In the Kingdom of Saudi Arabia so far has one family identified to have Haplogroup R2A (R-M124) of its paternal genome or Y-Chromosome updated 5 January; 2018.
Position on the ISOGG tree and related SNPs
Haplogroup R-M124 is a subgroup of Haplogroup R-M479 (M479):
- R-M479 (M479)
- R-M124 (M124, P249, P267, L266)
- R-L295 (L295)
- R-L263 (L263)
- R-L1069 (L1069)
- R-M124 (M124, P249, P267, L266)