Hemetsberger indole synthesis
Chemical reaction
From Wikipedia, the free encyclopedia
The Hemetsberger indole synthesis (also called the Hemetsberger–Knittel synthesis) is a chemical reaction that thermally decomposes a 3-aryl-2-azido-propenoic ester into an indole-2-carboxylic ester.[1][2]
| Hemetsberger indole synthesis | |
|---|---|
| Named after | Helfried Hemetsberger |
| Reaction type | Ring forming reaction |
Yields are typically above 70%. However, this is not a popular reaction, due to the lack of stability and difficulty in synthesizing the starting material.