HSPA13

Heat shock 70 kDa protein 13 is a protein that in humans is encoded by the HSPA13 gene.^[5][6]

AliasesHSPA13, STCH, heat shock protein family A (Hsp70) member 13

External IDsOMIM: 601100; MGI: 1309463; HomoloGene: 5062; GeneCards: HSPA13; OMA:HSPA13 - orthologs

Chr.Chromosome 21 (human)^[1]

End14,383,484 bp^[1]

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HSPA13
Identifiers
Aliases	HSPA13, STCH, heat shock protein family A (Hsp70) member 13
External IDs	OMIM: 601100; MGI: 1309463; HomoloGene: 5062; GeneCards: HSPA13; OMA:HSPA13 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q11.2 Start 14,371,115 bp[1] End 14,383,484 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 C3.1|16 43.36 cM Start 75,542,319 bp[2] End 75,563,992 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone cartilage tissue islet of Langerhans ganglionic eminence endothelial cell corpus epididymis retinal pigment epithelium beta cell caput epididymis orbitofrontal cortex Top expressed in hand lacrimal gland seminal vesicula superior cervical ganglion otolith organ arcuate nucleus median eminence utricle cumulus cell dermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein binding ATP binding ATPase activity heat shock protein binding protein folding chaperone activity unfolded protein binding misfolded protein binding Cellular component extracellular exosome endoplasmic reticulum intracellular membrane-bounded organelle nucleus cytoplasm endoplasmic reticulum lumen membrane endoplasmic reticulum chaperone complex Biological process response to unfolded protein ubiquitin-dependent ERAD pathway endoplasmic reticulum unfolded protein response cellular response to heat Unfolded Protein Response protein refolding chaperone cofactor-dependent protein refolding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6782 110920 Ensembl ENSG00000155304 ENSMUSG00000032932 UniProt P48723 Q8BM72 RefSeq (mRNA) NM_006948 NM_030201 RefSeq (protein) NP_008879 NP_084477 Location (UCSC) Chr 21: 14.37 – 14.38 Mb Chr 16: 75.54 – 75.56 Mb PubMed search [3] [4]
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The protein encoded by this gene is a member of the heat shock protein 70 family and is found associated with endoplasmic reticulum. Members of this protein family play a role in the processing of cytosolic and secretory proteins, as well as in the removal of denatured or incorrectly folded proteins. The encoded protein contains an ATPase domain and has been shown to associate with a ubiquitin-like protein.^[6]