Hyponitrite reductase

In enzymology, a hyponitrite reductase is an enzyme that catalyzes the oxidation of hydroxylamine H
₂NOH by the nicotinamide adenine dinucleotide cation (NAD⁺) into hyponitrous acid HON=NOH:

2 H
₂NOH + 2 NAD⁺ ${\displaystyle \rightleftharpoons }$ HON=NOH + 2 NADH + 2 H⁺

This systematic name of this enzyme class hydroxylamine:NAD+ oxidoreductase. It is also called NADH2:hyponitrite oxidoreductase.

This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with NAD+ or NADP+ as acceptor. It employs one cofactor, metal.