Inositol monophosphatase 2

Inositol monophosphatase 2 is a 32 kDa enzyme that in humans is encoded by the IMPA2 gene.^[4][5] IMPA2 dephosphorylates myo-inositol monophosphate to myo-inositol.

AliasesIMPA2, inositol monophosphatase 2

External IDsOMIM: 605922; MGI: 2149728; GeneCards: IMPA2

PDBOrtholog search: A0A6I8PI91 PDBe A0A6I8PI91 RCSB

Chr.Chromosome 18 (human)^[1]

Quick facts IMPA2, Identifiers ...

IMPA2
Identifiers
Aliases	IMPA2, inositol monophosphatase 2
External IDs	OMIM: 605922; MGI: 2149728; GeneCards: IMPA2
Available structures PDB Ortholog search: A0A6I8PI91 PDBe A0A6I8PI91 RCSB List of PDB id codes 2CZH, 2CZI, 2CZK, 2DDK, 2FVZ
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 3.1.3.25 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18p11.21 Start 11,981,025 bp[1] End 12,030,877 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas skin of abdomen gastrocnemius muscle skin of leg muscle of thigh human kidney vulva skin of thigh Skeletal muscle tissue of rectus abdominis mucosa of transverse colon n/a More reference expression data BioGPS n/a
Gene ontology Molecular function inositol monophosphate 1-phosphatase activity inositol monophosphate phosphatase activity hydrolase activity protein binding protein homodimerization activity metal ion binding inositol monophosphate 3-phosphatase activity inositol monophosphate 4-phosphatase activity Cellular component cytoplasm cytosol Biological process phosphate-containing compound metabolic process phosphatidylinositol phosphate biosynthetic process inositol phosphate metabolic process inositol metabolic process inositol biosynthetic process signal transduction inositol phosphate dephosphorylation Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 3613 114663 Ensembl ENSG00000141401 n/a UniProt O14732 Q91UZ5 RefSeq (mRNA) NM_014214 NM_053261 RefSeq (protein) NP_055029 NP_444491 Location (UCSC) Chr 18: 11.98 – 12.03 Mb n/a PubMed search [2] [3]
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The function of IMPA2 appears to be similar to IMPA1 within tissues; however, the genes are expressed differently in various tissues with IMPA2 expressed at the highest level in certain tissues of the brain and the lumen of the kidney. IMPA2 exists as a homodimer within cells and cannot form heterodimers with IMPA1.^[6]